Conclusions: Differences between the sexes in lower extremity alignment and muscle activation occur during the soccer instep and side-foot kicks. Decreased activation of the hip abductors and greater hip adduction in the supporting limb during the soccer kick in female athletes may be associated with their increased risk for anterior cruciate ligament injury. Clinical Relevance: Programs targeting these differences in muscle activation and lower extremity alignment during the kick should be evaluated for use in injury prevention in soccer athletes. Future research is warranted to investigate how differences between the sexes at the hip may relate to differences in the risk of lower extremity injury among athletes in soccer and other sports. (Source: JBJS [Am])